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CS DEPARTMENT COLLOQUIUMWhen: Friday, October 27, 3-4 pmWhere: CS Conferenece Room, Phillips Hall 736 Speaker: Dr. Sridhar Hannenhalli, Assistant Professor, Department of Genetics, University of Pennsylvania Title: Deciphering Gene Regulatory Networks by in silico approaches Abstract: Biological processes are controlled at various levels in the cell and while these mechanisms are poorly understood, transcriptional control is widely recognized as an important component and a better understanding of which will provide an efficient means for the therapeutic intervention in disease processes. We have been focusing on various computational problems pertaining to transcriptional regulation, namely, (1) representation and identification of transcription factor binding sites, (2) PolII promoter prediction, (3) Predicting interaction among transcription factors, (4) Transcriptional modeling, i.e. identifying arrangements of TFs that co-regulate a set of transcripts. I will present a brief overview of the computational approaches and challenges as well as applications to transcriptional regulation in memory storage and heart failure. Speaker Bio: Dr. Hannenhalli received his PhD in 1996 in Computer Science from Penn State University. After a postdoctoral fellowship at the University of Southern California, he worked six years in the industry as a computational biology researcher, first at Glaxo SmithKline and then at Celera Genomics. Dr. Hannenhalli joined the Department of Genetics in the School of Medicine at the University of Pennsylvania, where he is currently an Assistant Professor of Bioinformatics. |
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